《應用生理學雜志》發表了涉及應用生理學各個領域的原始論文，特別是那些強調適應性和整合機制的論文。適應性生理學包括1）與發育、衰老和病理生理條件有關的固有適應；2）對外部環境的適應，如運動、微重力、低氧、低氣壓和高氣壓以及低熱和高熱條件。整合生理學包括1）跨器官系統的橫向整合；2）從分子到細胞到器官的縱向整合。在應用生理學的所有領域，強烈鼓勵使用包括分子生物學和細胞生物學在內的尖端技術。

The Journal of Applied Physiology publishes original papers that deal with diverse areas of research in applied physiology, especially those emphasizing adaptive and integrative mechanisms. Adaptive physiology includes 1) inherent adaptations such as those related to development, aging, and pathophysiological conditions and 2) adaptations to the external environment such as those occurring with exercise, microgravity, hypoxia, hypo- and hyperbaria, and hypo- and hyperthermic conditions. Integrative physiology includes 1) horizontal integration across organ systems and 2) vertical integration from molecule to cell to organ. In all areas of applied physiology, the use of cutting-edge techniques including molecular and cellular biology is strongly encouraged.