系統生物學是一門綜合學科，它試圖從復雜生物系統的組成和相互作用的角度來解釋復雜生物系統的特性和行為。分子系統生物學是一個同行評審的開放獲取期刊，出版高質量的研究領域的系統生物學，合成生物學和系統醫學。編輯根據稿件的新穎性和廣泛的生物學意義來選擇稿件。雖然該雜志的主要重點是分子組成及其相互作用，但也可考慮在器官一級進行系統研究。描述大型數據集的作品將在一定程度上通過這些數據集彼此之間以及與計算模型的集成程度來進行評判，最終目的是更好地理解生命系統的動態和復雜本質。新實驗方法的報告也將在這項政策的范圍內加以審議。

Systems biology is an integrative discipline that seeks to explain the properties and behaviour of complex biological systems in terms of their components and their interactions. Molecular Systems Biology is a peer-reviewed open access journal that publishes high-quality research in the fields of systems biology, synthetic biology and systems medicine. The Editors select manuscripts based on their novelty and wide biological significance. Although the primary emphasis of the journal is on molecular components and their interactions, systems studies at the organ level may also be considered. Works describing large-scale datasets will be judged, in part, by the extent to which these datasets are integrated both with each other and with computational models, with the ultimate aim to better understand the dynamic and complex nature of living systems. Reports of new experimental methods will also be considered in the context of this policy.