生物物理學的季度回顧涵蓋了實驗和計算生物物理學領域。實驗生物物理學跨越不同的物理基礎測量，如光學顯微鏡，超分辨率成像，電子顯微鏡，x射線和中子衍射，光譜學，量熱學，熱力學及其綜合應用。計算生物物理學包括理論、模擬、生物信息學和系統分析。這些生物物理方法被用來發現從細胞、細胞器、膜、蛋白質核酸復合物、分子機器到分子等各種復雜的生物系統的結構、功能和生理。大多數發表的評論都是邀請對該領域做出重大貢獻的作者發表的，他們對自己專業領域的最新進展和問題進行了批判性的、可讀性強的、有時甚至是有爭議的描述。該雜志在ISI科學引文索引中排名靠前，是不同領域的生物物理學家之間進行一般性和專業性交流的論壇，在世界范圍內享有長期的聲譽。專題期刊偶爾出版。

Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.