心力衰竭發表心力衰竭患者的病理生理學、診斷、治療和護理方面最重要的發現。該雜志的目標是通過及時、深刻的科學交流，增進我們對疾病、臨床試驗、臨床結果和治療進展的了解。該雜志涵蓋了神經科學、肺醫學、腎臟學、電生理學和外科等與心力衰竭相關的跨學科關系。此外，該雜志還包括有關藥物遺傳學、生物標志物和代謝組學的文章。

Heart Failure publishes the most important findings on the pathophysiology, diagnosis, treatment, and care of heart failure patients. The goal of the Journal is to improve our understanding of the disease, clinical trial, clinical outcomes, and advances in therapies through timely, insightful scientific communication. The Journal embraces interdisciplinary relationships with neuroscience, pulmonary medicine, nephrology, electrophysiology, and surgery as they relate to heart failure. In addition, the Journal includes articles concerning pharmacogenetics, biomarkers, and metabolomics.